Genetic overlap between schizophrenia and developmental psychopathology: a longitudinal approach applied to common childhood disorders between age 7 and 15 years
نویسندگان
چکیده
1. Biological Psychology, VU University, Amsterdam, The Netherlands 2. MRC Integrative Epidemiology Unit at the University of Bristol, UK 3. UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK 4. EMGO Institute for Health and Care Research (EMGO+), VU University Medical Center, Amsterdam, The Netherlands 5. Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands, 6. Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands 7. Department of Child and Adolescent Psychiatry, GGZ inGeest / VU University Medical Centre, Amsterdam, The Netherlands *: Correspondence should be addressed to Michel G Nivard Van der Boechorstraat 1081 BT Amsterdam, The Netherlands. [email protected]
منابع مشابه
Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development.
Background Several nonpsychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the etiology of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by correlated genetic risk factors. Methods Polygenic risk scores (PRS), reflecting an individua...
متن کاملDevelopmental Changes Within the Genetic Architecture of Social Communication Behavior: A Multivariate Study of Genetic Variance in Unrelated Individuals
BACKGROUND Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We develope...
متن کاملA twin study exploring the association between childhood emotional and behaviour problems and specific psychotic experiences in a community sample of adolescents.
BACKGROUND Childhood emotional and behaviour problems are antecedents for later psychopathology. This study investigated genetic and environmental influences shaping the longitudinal association between childhood emotional and behaviour problems and specific PEs. METHOD In a community-based twin sample, parents reported on emotional and behaviour problems when twins were ages 7 and 12 years. ...
متن کاملAge of onset of schizophrenia: perspectives from structural neuroimaging studies.
Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of onset in late adolescence. Late adolescence may reflect a critical period in brain development making it particularly vulnerable for the onset of psychopathology. Neuroimaging studies that focus on this age range may provide unique insights into the onset and course of psychosis. In this review, we exam...
متن کاملمقایسه تغییرات بیلیروبین در اسکیزوفرنیا و اختلال خلقی دوقطبی نوع یک
AbstractObjectives: The aim of this study was to evaluate bilirubin level changes in patients with schizophrenia and other psychotic disorders. Method: This was a comparative cross-sectional study. Hospitalized patients of at least 20 years of age, with the primary diagnosis of psychosis, were first evaluated using Structured Clinical Interview DSM-IV for Axis I disorders (SCID-I) and 162 patie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016